The President signed Executive Order 14363 on Nov. 24, 2025, establishing the Genesis Mission, a national effort to speed the use of artificial intelligence for scientific discovery. The order was published in the Federal Register on Nov. 28, 2025. It does not revoke or amend any earlier order.
The order says the mission will build an integrated artificial intelligence platform that uses federal scientific datasets to train scientific foundation models and create AI agents. Those agents would test hypotheses, automate research workflows, and speed breakthroughs, the order says. It describes the effort as joining national laboratories, businesses, universities, and existing research sites.
The Secretary of Energy is responsible for carrying out the mission inside the Department of Energy, the order says. That includes setting priorities and, as appropriate and authorized by law, bringing Energy Department resources used for the mission into a secure, unified platform. The secretary may name a senior political appointee to oversee day-to-day operations.
The Assistant to the President for Science and Technology is to provide general leadership, the order says. The assistant is to coordinate participating agencies through the National Science and Technology Council and issue guidance so the mission aligns with national objectives.
The order directs the Energy secretary to establish and operate the American Science and Security Platform as the mission’s infrastructure. To the maximum extent practicable and consistent with law, the platform is to provide high-performance computing, AI modeling and analysis tools, computational tools, scientific foundation models, secure access to datasets, and experimental and production tools. The secretary must also take steps so the platform meets security requirements tied to its national security and competitiveness mission.
Several deadlines run from the date of the order. Within 90 days, the secretary must identify federal computing, storage, and networking resources available for the mission, including department systems and resources available through industry partners. Within 120 days, the secretary must identify an initial set of data and model assets and develop a plan, with risk-based cybersecurity measures, for adding data collections from research the federal government has funded, from other agencies, from colleges and universities, and from private partners that have been approved.
Within 240 days, the secretary must review what the Energy Department’s national labs and other federal research sites taking part can do with robot-run laboratories and manufacturing plants that can support AI-directed experimentation and manufacturing. Within 270 days, consistent with law and subject to available appropriations, the secretary must seek to demonstrate an initial operating capability for at least one national challenge identified under the order.
Within 60 days, the secretary must send the assistant a detailed list of at least 20 science and technology challenges of national importance. The order says the challenges must span priority domains consistent with a National Science and Technology Memorandum dated Sept. 23, 2025, including advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion energy, quantum information science, and semiconductors and microelectronics.
Within 30 days after that submission, the assistant must review the list and, with participating agency members of the council, coordinate an expanded list that can serve as the mission’s initial set of challenges. Participating agencies are then to use the platform to advance research aligned with those challenges, consistent with law and their missions and subject to available appropriations. Each year after that, the secretary is to review and update the list with the assistant and the council.
The assistant, through the council and with support from the Federal Chief Data Officer Council and the Chief AI Officer Council, is to convene interested agencies. That work includes aligning AI-related programs and datasets with the mission, identifying data sources, planning how to integrate agency data and infrastructure, and launching coordinated funding opportunities or prize competitions where law permits and appropriations are available.
The assistant is also to coordinate competitive programs for research fellowships, internships, and apprenticeships focused on applying AI to the identified scientific domains, including placements at national laboratories and other participating federal facilities. Those programs are subject to existing authorizing statutes and available appropriations, the order says.
The Energy secretary, with the assistant and the Special Advisor for AI and Crypto, is to set up collaboration with outside partners that have advanced AI, data, or computing capabilities or scientific expertise. The order says those arrangements must protect federal research assets and maximize public benefit, and it directs standard partnership frameworks, intellectual-property policies, cybersecurity standards for non-federal users, and vetting procedures. The assistant, through the council, is to identify opportunities for international scientific collaboration to the extent appropriate.
Within one year, and each year after that, the Energy secretary must report to the President through the assistant and the director of the Office of Management and Budget. The report is to cover the platform’s status, integration across laboratories and partners, user engagement, research outcomes, public-private partnerships, and any needs for authorities or interagency support. The order says it must be carried out consistent with applicable law and subject to available appropriations, and that it creates no enforceable right or benefit.