Substances Generally Recognized as Safe

Open for public comment until Dec. 9, 2026. Comment on Regulations.gov

What it does

The Food and Drug Administration (FDA or we) is proposing to require the submission of generally recognized as safe (GRAS) notices for the use of a human or animal food substance purported to be GRAS under the conditions of its intended use under the Federal Food, Drug, and Cosmetic Act (FD&C Act).

The Food and Drug Administration's summary, as published in the Federal Register.

What it would change

2 parts of Title 21 of the Code of Federal Regulations:

21 CFR 170, 21 CFR 570

Before this

No earlier Federal Register document under regulation identifier 0910-AJ02 since Jan. 1, 2025.

What happens next and when

Either electronic or written comments on the proposed rule must be submitted by December 9, 2026. Submit comments (including recommendations) on the collection of information under the Paperwork Reduction Act of 1995 by December 9, 2026.

The agency's dates, word for word.

Check it yourself

• The document in the Federal Register
• Docket FDA-2025-N-3262 on Regulations.gov
• Title 21 on eCFR

The record as published

Source: the Federal Register (public domain). The document in the Federal Register