Schedules of Controlled Substances: Temporary Placement of O-Desmethyltramadol in Schedule I

What it does

The Drug Enforcement Administration issues this temporary order to schedule O-desmethyltramadol (other names: O-DSMT; desmetramadol; 3-[(1R,2R)-2-[(dimethylamino)methyl]-1- hydroxycyclohexyl]phenol), including its isomers, esters, ethers, salts, and salts of isomers, esters and ethers, in schedule I of the Controlled Substances Act. DEA bases this action on a finding that placing O-DSMT in schedule I is necessary to avoid an imminent hazard to public safety. This order imposes the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle O-DSMT.

The Drug Enforcement Administration's summary, as published in the Federal Register.

What changed in the regulation

1 part of Title 21 of the Code of Federal Regulations:

21 CFR 1308

Wording on eCFR: the day before it took effect and from the day it took effect (first part listed).

Compared with

The Drug Enforcement Administration has published 26 final rules in 2026 so far, compared with 17 in all of 2025.

Counted by the Tribune from Federal Register records since Jan. 1, 2025.

What happens next and when

This temporary order is effective August 12, 2026, until August 12, 2028. If this order is extended or made permanent, DEA will publish a document in the Federal Register.

The agency's dates, word for word.

Check it yourself

• The document in the Federal Register
• Docket DEA-2026-0958 on Regulations.gov
• Title 21 on eCFR

The record as published

Source: the Federal Register (public domain). The document in the Federal Register