Global Benchmark for Efficient Drug Pricing (GLOBE) Model

What it does

This final rule implements the Global Benchmark for Efficient Drug Pricing Model (GLOBE Model), a new mandatory Medicare payment model under section 1115A of the Social Security Act. The GLOBE Model will test whether a payment model that uses an alternative method for calculating Medicare Part B drug inflation rebate amounts for certain separately payable Medicare Part B drugs and biological products reduces costs for Original Medicare (OM) beneficiaries and the Medicare program while preserving quality of care. The term OM has the same meaning as Medicare fee-for-service and the traditional Medicare program.

The Centers for Medicare & Medicaid Services's summary, as published in the Federal Register.

What changed in the regulation

1 part of Title 42 of the Code of Federal Regulations:

42 CFR 513

Compared with

The Centers for Medicare & Medicaid Services has published 24 final rules in 2026 so far, compared with 12 in all of 2025.

Counted by the Tribune from Federal Register records since Jan. 1, 2025.

Before this

1 earlier Federal Register document under regulation identifier 0938-AV66 since Jan. 1, 2025.

• Dec. 23, 2025 Proposed rule. Global Benchmark for Efficient Drug Pricing (GLOBE) Model

What happens next and when

These regulations are effective on November 30, 2026.

The agency's dates, word for word.

Check it yourself

• The document in the Federal Register
• Docket CMS-2025-1889 on Regulations.gov
• Title 42 on eCFR

The record as published

Source: the Federal Register (public domain). The document in the Federal Register